Carica papaya Linn.
Family
Caricaceae.
Habitat Native to West Indies and
Central America; now cultivated in
Uttar Pradesh, Punjab, Rajasthan,
Gujarat, Maharashtra and South
India.
English Papaya, Papaw.
Ayurvedic Erand-karkati, Papitaa.
Unani Papitaa Desi.
Siddha/Tamil Pappaali, Pappayi. Action Ripe fruit—stomachic,
digestive, carminative, diuretic, galactagogue. Useful in bleeding piles, haemoptysis, dysentery
and chronic diarrhoea. Seeds— emmengagogue, abortifacient, vermifuge. Juice of seeds is administered in enlarged liver and spleen, and in bleeding piles.
Key application Papain, the
enzyme mixture extracted from raw papain (latex of
Carica papaya), has been included among unapproved herbs by German Commission E.
Experiment-based as well as clinical

research indicate that papain may be effective (in the treatment of inflammations) in high doses (daily dose 1500 mg corresponding to 2520 FTP units).
Unripe fruit—emmengagogue and abortifacient. Latex—applied topically on eczema, ringworm, psoriasis, corns, warts, sloughing wounds, carbuncles and eschar of burns.
Green parts of the plant and seed contain an alkaloid carpaine. Seeds also contain carpasemine.
Latex contain enzymes—papain and chymopapain and alkaloids carpaine and pseudocarpaine. A proteinaceous material from latex showed anticoagulant activity; in higher doses it is heart depressant and as a spasmogen on smooth muscle of guinea pig ileum. An alkaloid solution showed depressant action on heart, blood pressure and intestine.
The anthelmintic action of seeds against
Ascaris lumbricoides is due to carpasemine.
Papain, an enzyme mixture prepared from the fruit, seeds and leaf, hydrolyses polypeptides, amides and esters, particularly when used in an alkaline environment, and is used in digestive disorders.
Papain inhibits platelet aggregation, which may further increase the risk of bleeding in patients also taking anticoagulants. Concurrent administration of cyclophosphamide with papain caused sever

Encyclopedia of Ayurvedic Medicinal Plants

A Candle of Medicinal Herb’s Identification and Usage